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Growth of Several Human Cell Lines in Newborn Rats^*

( Sloan-Kettering Institute for Cancer Research, New York, New York)

When injected intravenously into newborn rats, eight human tissue-cultured cancer cell lines—H.Ep. #2, Detroit 6, J-111, RP 41, RP 212, Adeno Cx 1, Ovary 2, and MAC 21—grew progressively in lung and other organs of more than 50 per cent of the animals and commonly cuased death after 5–8 weeks. Two other human cell lines—the carcinoma H.Ep. #1 and the presumably normal Amnion B—grew less frequently and rarely caused death or illness.

^* These studies were supported in part by a research grant # CY-3215 from the National Cancer Institute of the National Institutes of Health, United States Public Health Service; and by the Phoebe Waterman Fund. The authors are also indebted to the several investigators who isolated and supplied the cell lines, to the Cappell Laboratories (West Chester, Pennsylvania) for supplying all of the HeLa cell cultures, and to Mr. Roller Bailey of this laboratory for the fluorescein-labeled antibody studies.

Received 10/10/63.