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The Anti-Tumor Activity of 2-Keto-3-ethoxybutyraldehyde Bis(thiosemicarbazone) and Related Compounds^*

( The Biochemical Research Division of The Upjohn Company, Kalamazoo, Michigan)

2-Keto-3-ethoxybutyraldehyde bis(thiosemicarbazone) (KTS) has been shown to have marked carcinostatic and carcinolytic activity against several established rat tumors. Dose-response relationships have been established for its toxicity, tumor-inhibitory activity, and capability of causing regressions. The compound is more safely administered via the oral route than by intraperitoneal injection.

The activity of KTS is compared with several related compounds, and some indications of structural requirements for biological activity are noted.

^* This paper was presented in part at the Meeting of the Federation of American Societies for Experimental Biology in Atlantic City, 1962.

Received 7/ 5/63.

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