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Histogenesis of Thymic Lymphoma Induced by a Murine Leukemia Virus (Rich)^*

( Laboratory of Cancer Research, Albert Einstein Medical Center, Philadelphia, Pennsylvania)

Following inoculation of a newly isolated murine leukemia virus (Rich), lymphoma evolved in the thymuses of BALB/c mice. Tumor evolution occurred unilaterally in only one of the two paired thymus glands. Unilateral thymic lymphocyte depletion and unilateral thymic lymphoma in situ preceded the appearance of the unilateral lymphoma. Most cells of one thymus, but no cells of the opposite thymus, evolved into tumor, suggesting that the leukemogenic effect of the virus on the thymic cells was indirect.

The period of tumor evolution and early dissemination was unmarked by apparent illness. In this system the development of anemia and the presence of tumor cells in the peripheral blood stream, lymph nodes, and bone marrow are very late manifestations of the lymphoma.

^* This study was supported by grants from the Department of Radiology, Albert Einstein Medical Center, Philadelphia, and the National Institutes of Health (CA 06711-01A1).

Received 9/21/63.

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				M. A. Rich, R. Tsuchida, and R. Siegler Chromosome Aberrations: Their Role in the Etiology of Murine Leukemia Science, October 9, 1964; 146(3641): 252 - 253. [Abstract] [PDF]