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Phthalanilide Inhibition of Protein Synthesis in a Cell-free L1210 Mouse Ascites Leukemia System^*

( Department of Medicine, Columbia University College of Physicians and Surgeons, and Francis Delafield Hospital, New York, N. Y.)

The incorporation of amino acids into polypeptides was inhibited in cell-free extracts of L1210 cells from mice pretreated with 2-chloro-4'-4''-di-2-imidazolin-2-yl terephthalanilide. The impairment of the protein synthetic reactions was found both in the presence of endogenous informational RNA and following the addition of polyuridylic and polyadenylic acids. The site of inhibition of the protein synthetic capacity was localized to the microsomes.

^* This research was supported in part by a grant from the National Cancer Institute of the National Institutes of Health, U. S. Public Health Service (CY-2332), and the Alma Toorock Memorial Fund.

Received 10/ 3/63.