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Studies on Induced Resistance against Isotransplants of Virus-induced Leukemia^*

J. P. Glynn, A. R. Bianco and A. Goldin

( Drug Evaluation Branch, Cancer Chemotherapy National Service Center, National Cancer Institute, Bethesda, Maryland)

The antigenicity of several well established Moloney virus-induced transplantable leukemias was studied. Resistance was developed by pretreatment of isologous mice with x-radiated tumor tissue. In general, the neoplasms grew more rapidly in pre-irradiated mice (400 r) than in normal mice, and at low inoculum concentrations a higher percentage of tumors was observed in the pre-irradiated animals. Different Moloney virus-induced leukemias were shown to cross-react. The resistance developed by pretreatment with x-radiated tumor suspensions of Moloney virus-induced leukemias did not inhibit the growth of a leukemia induced by the Rauscher virus. In BALB/c mice infected with Moloney virus transient interference with the growth of an isologous Moloney virus-induced leukemia was observed.

^* Presented in part at the 54th Annual Meeting, American Association for Cancer Research, Toronto, Canada, May 23–25, 1963.

Visiting Associate from Institute of Medical Pathology, University of Naples, Naples, Italy.

Formerly Biochemical Pharmacology.

Received 10/17/63.

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