This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moore, A. E. Articles by Caparó, A. C. Search for Related Content PubMed PubMed Citation Articles by Moore, A. E. Articles by Caparó, A. C.

Tumors Occurring in Newborn Mice after Inoculation of Human Cancer Material^*

Alice E. Moore and Alberto Cuba Caparó

( Sloan-Kettering Institute for Cancer Research, New York, N. Y.

Filtrates and tissue culture preparations made from 208 specimens obtained from patients with cancer, benign lesions, and normal tissues were inoculated into 3990 newborn mice. Ten and two-tenths per cent of animals given inoculations of preparations from lymphoma patients developed tumors, as compared with 4.3 per cent for the uninoculated controls. No other group of tumors showed a significant increase, nor did they appear significantly earlier in any group. The mice developed mammary adenocarcinomas and lymphosarcomas that often were limited to the thymus. Since Friend has demonstrated a virus in lymphosarcomas which arose in the same animal stocks at the same time, the authors believe the increased number of tumors in the inoculated animals was due to an activation of tumor viruses already present.

^* This work was supported by grant C-1355 from the National Cancer Institute, National Institutes of Health, Public Health Service.

Present address: San Marcos University, Lima, Peru.

Received 9/27/63.