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The Relationship between the Dissemination of Tumor Cells and the Distribution of Metastases^*

( Department of Pathology, Yale University School of Medicine, New Haven, Connecticut)

The dissemination of tumor cells in blood and organs was determined at intervals after the vascular invasion of transplanted tumors and the intravenous inoculation of tumor cell suspensions. Determinations were based on the incidence of tumor growth in fragments of various organs transplanted to normal animals. It was found that distinct patterns of tumor cell distribution differentiated the tumors studied into two groups. In one group, the distribution was limited to organs that subsequently became the site of metastases, whereas the other was characterized by a widespread organic distribution of cells, occurring without relationship to the eventual location of metastases. These findings were related to other known characteristics of the tumors in an attempt to determine the nature of organ retention.

^* Research supported by the Jane Coffin Childs Fund for Medical Research, the United States Public Health Service, and the American Cancer Society.

Received 11/26/63.

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