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Serum Properdin in Tumor-bearing Mice. I. Comparison with Natural and Immune Antibodies^*

( Research Laboratories, Departments of Radiology and Laboratories, Albert Einstein Medical Center, Philadelphia 47, Pennsylvania)

Growth of a transplanted, isologous mammary carcinoma resulted in depressed titers of serum properdin and Shigella paradysenteriae antibody in mice. This tumor had no apparent deleterious influence on natural antisheep hemagglutinins. Tumor antigen preparations did not produce these effects. The likelihood that these alterations in immune response are secondary rather than direct effects is suggested by their constant association in time with the preterminal state and by the observation that properdin levels could be preserved by zymosan injections without influencing tumor growth.

^* This work was supported by Grant CA 04653-03 AI from the National Institutes of Health, U. S. Public Health Service.

Received 12/ 6/63.