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Serum Properdin in Tumor-bearing Mice. II. The Influence of Tumors of Different Origin^*

( Research Laboratories, Departments of Radiology and Laboratories, Albert Einstein Medical Center, Philadelphia 47, Pennsylvania)

The growth of three tumors, of different cell type and origin, was associated with low levels of serum properdin in mice. This relationship was not observed in mice bearing a myeloid leukemia. Shigella antibody titers also remained relatively unaltered in the latter animals. Depression in properdin occurred toward the end of survival, at a time when the tumor hosts had reduced their food consumption and were losing weight. Similar serological changes could be produced by food deprival; this finding suggests that the relationship is probably nonspecific.

^* This work was supported by Grant CA 04653-03 AI from the National Institutes of Health, U. S. Public Health Service.

Received 12/ 6/63.