This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wahren, B. Search for Related Content PubMed PubMed Citation Articles by Wahren, B.

Further Studies of the Immunological Properties of Gross Virus-induced Lymphomas^*

( Institute for Medical Cell Research and Genetics, Karolinska Institute, Stockholm, Sweden)

The previously demonstrated antigenicity of Gross virus-induced lymphomas was further investigated. It was found that Gross virus homogenate was less potent than living lymphoma cells. When, however, concentrated fractions of the same homogenate were used for pretreatment, both cytotoxic sera and resistance against isogenic transplantation were provoked. Evidence was obtained that cellular constituents rather than virus in its pure form are responsible for the induction of specific cytotoxic antibodies and transplantation resistance. When cytotoxic sera were assayed for virusneutralizing capacity, no effect was found.

When cross experiments were performed between Gross and polyoma virus and Gross and polyoma tumor antigens no serological relationship could be detected.

^* This work was supported by research grants from the Wallenberg Foundation and U. S. Public Health Service, grant C-4716.

Received 1/14/64.