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Radioactive Estrogens in Tissues of Postmenopausal Women with Breast Neoplasms^*

( Department of Surgery and Biochemistry, School of Medicine, University of Southern California and the Tumor Service of the Los Angeles County General Hospital, Los Angeles, California)

Following the intravenous administration of estradiol-17ß-4-C¹⁴ to postmenopausal women with mammary carcinoma, the concentrations of total radioactive estrogen and the individual radiometabolites estradiol and estrone, and an uncharacterized fraction (E_p), were determined in several body tissues. Specimens of mammary tissue, mammary tumor, abdominal fat, muscle, and skin were removed 30 minutes after the infusion of the radioactive hormone. The median concentration of radioactive hormone in the tissues 30 minutes after the infusion of 680 µg. of radioactive estradiol was 6.5 mµg/gm of tissue. Average concentrations of estradiol, estrone, and E_p fraction were 76, 12, and 12 per cent, respectively.

Although there was considerable variation in the amounts of radioactive estrogen in the tissues analyzed, generally greater amounts of radioactivity were found in the malignant tumor in comparison to mammary tissue and body fat tissues. The mean per cent estradiol in malignant tumor was greater than the amounts present in the other tissues.

A method is described for the analysis of radioactive estrogens in tissue specimens.

^* This investigation was supported by research grant C-2489 from the National Cancer Institute, National Institutes of Health, U. S. Public Health Service.

Received 2/27/64.