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The Effect of Dietary Copper on Rat Carcinogenesis by 3-Methoxy Dyes

I. Tumors Induced at Various Sites by Feeding 3-Methoxy-4-aminoazobenzene and Its N-Methyl Derivative^*

( Cancer Research Laboratories, Department of Pathology, Medical School, Birmingham, England)

Rats given 0.09 per cent 3-methoxy-4-aminoazobenzene in maize produced numerous tumors of the ear duct and liver, together with a smaller number of nonmalignant skin tumors. When 0.5 per cent cupric oxyacetate hexahydrate was also included in the diet, liver damage was much less, but the incidence of ear duct and skin tumors remained unchanged.

Animals treated with 3-methoxy-4-monomethylaminoazobenzene at the same concentration all produced car duct tumors irrespective of whether the copper salt was included. Liver damage was found only in rats receiving the dye alone, and no skin tumors were found in either group.

^* This work was supported by the Birmingham branch of the British Empire Cancer Campaign during the tenure by one of us (GF) of a Medical Research Council Training Scholarship.

Received 3/10/64.