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The Effect of 1-ß-D-Arabinofuranosylcytosine Hydrochloride on Murine Neoplasms

( Biological Research Division, The Upjohn Company, Kalamazoo, Michigan)

1-ß-D-Arabinofuranosylcytosine hydrochloride (Cytosine arabinoside, CA) was shown to be an effective inhibitor of Sarcoma 180, Ehrlich carcinoma, leukemias L1210 and L1210/C95, lymphoblast L5178Y, and the T-4 lymphoma. CA showed no significant activity against a spectrum of rat tumors or leukemias. Well established mouse tumors and leukemias, as well as recently transplanted neoplasias, were inhibited by the drug.

6-Mercaptopurine- and azaserine-resistant lines of Sarcoma 180 were inhibited by CA, indicating that the sites of metabolic action of the three drugs differ. Combination therapy with CA and 6-MP inhibited the normal and 6-MP-resistant lines of Sarcoma 180. The inhibition appeared to be more than additive.

Comparison of the activity of CA with other drugs used in the laboratory and the clinic showed that cytosine arabinoside is one of the most effective agents used in the control of recently transplanted or well established leukemias.

Received 3/26/64.

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				D. Kessel, T. C. Hall, and I. Wodinsky Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside Science, June 2, 1967; 156(3779): 1240 - 1241. [Abstract] [PDF]