This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Barclay, R. K. Articles by Sugiura, K. Search for Related Content PubMed PubMed Citation Articles by Barclay, R. K. Articles by Sugiura, K.

Synthesis of and Tumor Inhibition by a Tryptophan Mustard^*

( Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research; and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York, New York)

5-Bis(ß-chloroethyl)amino-DL-tryptophan ("tryptophan mustard") has been synthesized in improved yields and has been studied extensively for its anti-tumor effect in 32 solid tumors, two ascites tumors, and one virus leukemia. Tryptophan mustard had a complete inhibitory effect on both Ehrlich and Sarcoma 180 ascites tumors in the mouse, and on the Jensen sarcoma, Flexner-Jobling carcinoma, and Yoshida sarcoma in the rat. Its spectrum of activity is essentially the same as phenylalanine mustard (Melphalan). In comparison with nitrogen mustard (HN2), tryptophan mustard has a much wider therapeutic index.

^* This investigation was supported partially by Contract SA-43-ph-2445, Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health.

Received 2/12/64.