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Further Observation on the Role of Aneuploidy in Acute Leukemia^*

( Child Research Center of Michigan, Children's Hospital of Michigan, and the Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan)

Studies made before initiation of therapy and serial observations during consecutive relapses and intervening remissions in children with various types of leukemia are presented. Aneuploid stem lines were consistently demonstrable during the active stages of the disease, showing stability and occasionally traceable secondary evolution of modal numbers. The findings constitute further evidence for an association between neoplastic transformation and gross chromosomal abnormalities.

^* Supported by a grant from the Children's Leukemia Foundation of Michigan.

Presented in part at the Sixth Annual Meeting of the American Society of Hematology, Washington, D. C., December 8–10, 1963, and in part at the Conference on Obstacles to the Control of Acute Leukemia, American Cancer Society and National Cancer Institute, Airlie House, Warrenton, Virginia, March 21–23, 1964.

Received 4/ 3/64.