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Effect of Partial Hepatectomy on DNA Synthesis and Mitosis in Heterotopic Partial Autografts of Rat Liver^*

( U. S. Naval Radiological Defense Laboratory, San Francisco, California, and Washington University School of Medicine, St. Louis, Missouri)

Functioning, heterotopic, partial hepatic autografts without portal blood supply were used to investigate factors controlling regeneration of liver after partial hepatectomy in rats. Following partial hepatectomy DNA synthesis and mitosis in grafts were virtually identical to those occurring in residual livers of the same animals. These results are consistent with a regulatory mechanism controlling hepatocytic proliferation, active throughout the body and distributed through the systemic circulation (blood-borne). The nature, origin, and manner of action of the blood-borne mediator are not indicated by this study.

This study also confirms that portal blood and increased hepatic blood flow are unnecessary for proliferation of hepatocytes.

^* This investigation was supported in part by the Bureau of Medicine and Surgery, U. S. Navy, and in part by U. S. Public Health Service Research Grant AM-07568. Opinions contained herein are those of the authors and are not to be construed as official views of the Department of Defense.

Received 4/13/64.

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