This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Nichols, W. W. Search for Related Content PubMed PubMed Citation Articles by Nichols, W. W.

In Vitro Chromosome Breakage Induced by Arabinosyladenine in Human Leukocytes^*

( South Jersey Medical Research Foundation, Camden, New Jersey)

The induction of chromosome breaks by arabinosyladenine (araA) in human leukocytes is described. These chromosome breaks were of the type described as gaps and open breaks and were produced when the araA was added during the period of deoxyribonucleic acid (DNA) synthesis but not when the araA was added for a short period before the cells were undergoing DNA synthesis, although ribonucleic acid synthesis should have already been in progress. A brief comparison between araA and other nucleosides that are known to produce similar morphologic effects in made.

^* This work was supported in part by grants-in-aid from the National Institutes of Health CA-03845, CA-4953; and Research Career Development Award RC-17-64.

Received 4/18/64.