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Recognition of Altered Patterns of Messenger RNA Synthesis in a Mouse Hepatoma^*

Chev Kidson and K. S. Kirby

( Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, S. W.3. England)

Patterns of messenger RNA synthesis in a transplanted spontaneous BR6 mouse hepatoma have been compared with those of normal BR6 mouse liver by countercurrent distribution. The liver patterns showed little variation, whereas in the hepatoma there was progressive alteration in the messenger RNA profile with progression of the tumor. Evidence from countercurrent distribution profiles of liver and hepatoma DNA and from comparative rates of messenger RNA synthesis suggests that less of the tumor genome is being transcribed into messenger RNA. From the messenger RNA profiles on countercurrent distribution it is evident that, of those regions of the hepatoma genome which are undergoing transcription, many are different from those being transcribed in the normal liver.

^* This investigation was supported by grants to the Chester Beatty Research Institute (Institute of Cancer Research: Royal Cancer Hospital) from the Medical Research Council, The British Empire Cancer Campaign, and the National Cancer Institute of the National Institutes of Health, U. S. Public Health Service.

Arthur A. Thomas Cancer Research Fellow of the Anti-Cancer Council of Victoria, on leave from the Baker Medical Research Institute, Melbourne, Australia.

Received 3/27/64.