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Serum Mucoid Levels in Rats Bearing Walker Carcinoma 256 and the Effect of Surgical Extirpation of the Malignancy^*

( Department of Microbiology, Vanderbilt University, Nashville, Tennessee)

In rats given implants of Walker 256 tumor a sizable increase in tumor mass has been shown to precede significant increases in the serum mucoid levels. Surgical extirpation of the tumor leads to a return of the serum mucoids to normal values. If substantial metastasis has occurred, the serum mucoid values do not return to normal. If minimal amounts of tumor remain in situ or in unsuspected metastatic areas, then serum levels may fall to normal, only to rise again when substantial growth occurs. The chromatographic behavior of serum mucoids in tumor-bearing rats is shown to differ significantly from that of normal rat serum.

^* Supported in part by Institutional Cancer Grant General Fund VU 75-2080.

Received 5/ 2/64.