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Lack of Effect of Norethynodrel (Enovid) on Methylcholanthrene-induced Mammary Carcinogenesis in Female Rats^*

M. Gruenstein, H. Shay and M. B. Shimkin

( Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania)

Norethynodrel with mestranol (Enovid) fed to female Wistar rats, 3 mg. 6 times per week for up to 50 weeks, produced no neoplasms of the breast or other tissues and did not enhance or retard mammary carcinogenesis evoked by gastric instillations of 3-methylcholanthrene.

^* Supported in part by NIH Grant CA 02590.

Deceased July 30, 1963.

Received 5/18/64.