This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ward, D. N. Articles by Adams-Mayne, M. Search for Related Content PubMed PubMed Citation Articles by Ward, D. N. Articles by Adams-Mayne, M.

Estrogen-induced Kidney Tumors in the Golden Hamster

III. Luteinizing Hormone Levels in the Pituitary Gland during Tumorigenesis¹

Department of biochemistry, The University of Texas, M. D. Anderson Hospital and Tumor Institute, Houston, Texas

Prolonged diethylstilbestrol treatment, which produces renal tumors in the male golden hamster, also produces pituitary gland enlargement and decrease of luteinizing hormone content. The LH² level, measured by the ovarian ascorbic acid depletion method, went from an initial 6 units of LH per pituitary down to 0.2 unit after 7 months of diethylstilbestrol treatment.

¹ This investigation was supported by USPH Research Grants No. NCI-C-4212 from the National Cancer Institute and AM 3033 from the Institute for Arthritis and Metabolic Diseases. A preliminary report of portions of this study was presented earlier (Proc. Am. Assoc. Cancer Res., 4: 70, 1963).

² The following abbreviations are used: LH, luteinizing hormone (interstitial cell stimulating hormone); LTH, luteotropic hormone (prolactin); DES, diethylstilbestrol.

Received 4/ 5/65.