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The Effect of Dietary Copper on Rat Carcinogenesis by 3-Methoxy Dyes

II. Multiple Skin Tumors by Painting with 3-Methoxy-4-dimethylaminoazobenzene¹

Cancer Research Laboratories, Department of Pathology, Medical School, Birmingham 15, England

Ten rats painted twice weekly with 1 ml of 0.2% 3-methoxy-4-dimethylaminoazobenzene in acetone all developed multiple skin tumors irrespective of whether they were fed maize containing 0.5% cupric oxyacetate hexahydrate or maize alone. The average induction time was 46 weeks, but during the following 16 weeks large numbers of lesions occurred. these were usually keratinous and covered up to 5 sq cm of skin. All lesions were found within the painted area on the dorsal skin, and the histologic types of tumor were the same as have been found in rats treated with other carcinogens: squamous carcinoma, keratoacanthoma, and basal cell carcinoma sometimes with sebaceous or trichoepitheliomatous differentiation. Apart from 3 ear duct tumors, no lesions at other sites were detected.

¹ This work was supported by the Birmingham branch of the British Empire Cancer Campaign for Research during the tenure by one of us (G. F) of a Medical Research Council Training Scholarship.

Received 4/30/65.