This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schwartz, H. S. Articles by Philips, F. S. Search for Related Content PubMed PubMed Citation Articles by Schwartz, H. S. Articles by Philips, F. S.

Hydroxyurea: Inhibition of Deoxyribonucleic Acid Synthesis in Regenerating Liver of Rats¹

Division of Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, New York

Single, nonlethal doses of hydroxyurea are rapidly inhibitory to the incorporation of thymidine-2-¹⁴C and phosphate-³²P into DNA² of regenerating liver of the rat. The agent does not affect synthesis or sedimentation profiles of RNA, and it is not cytotoxic to liver under the conditions tested.

¹ This research was supported by Grant CA-03192 from the National Cancer Institute, USPHS.

² The following abbreviations are used: DNA, deoxyribonucleic acid; RNA, ribonucleic acid; TCA, trichloroacetic acid; Tris, tris(hydroxymethyl)aminomethane; SDS, sodium dodecylsulfate; ND, naphthalene disulfonate.

Received 5/ 6/65.