This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Van Duuren, B. L. Articles by Orris, L. Search for Related Content PubMed PubMed Citation Articles by Van Duuren, B. L. Articles by Orris, L.

The Tumor-enhancing Principles of Croton Tiglium L.¹

Institute of Environmental Medicine, New York University Medical Center, New York, New York

The extraction and isolation of 2 active cocarcinogenic agents from the seed of Croton tiglium L. and their long-term biologic testing are described. Both materials are potent cocarcinogens at very low dosages. The biologic activity of chemically transformed derivatives of the active materials is also reported. Phorbol myristate acetate, a semisynthetic compound derived from croton resin, showed notable promoting activity. Some aspects of the chemistry of the active materials are discussed.

¹ This work was supported by Grants CA-05946, CA-06989, and ES-00014 from the Department of Health, Education and Welfare, USPHS.

Received 5/ 6/65.