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Studies on Folic Reductase

II. Enzyme Activity of Embryonic Organs of the Chicken, Rat, and Human¹

Children's Cancer Research Foundation and Harvard Medical School, Boston, Massachusetts

The level of folate reductase activity in the liver of the chick embryo was highest during the earlier stages of development. The enzyme level of human fetal liver was higher than that previously reported for the adult. Lower levels of enzyme activity were observed in fetal human lung, kidney, viscera, heart, and adrenal. The level of activity in the rat embryo liver was similar to the levels observed in the liver of the adult. Folate reductase activity in embryo liver does not uniformly parallel mitotic rate in the species examined and is suggested to have a permissive role in cell divisions.

¹ This investigation was supported in part by Contract No. PH-43-62-169 from the Cancer Chemotherapy National Service Center, National Cancer Institute, NIH.

Received 6/19/64. Revised 6/24/65.