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The Incidence of Pathologic Abnormalities, Including Spontaneous Lymphosarcomas, in a Laboratory Stock of Xenopus (The South African Clawed Toad)¹

( Station for Experimental Zoology, University of Geneva, Chêne Bougeries, Geneva, Switzerland²)

Spontaneous pathologic abnormalities occurring in a laboratory colony of Xenopus were recorded and studied. These included granulomas, hematomas, hamartomas, cysts, hydrops disease, paralysis, and 81 cases of lymphosarcoma. The lymphosarcomas most commonly affected the liver, spleen, and kidneys, but also metastasized to other organs. Although the first tumors tended to be found in miscellaneous adult Xenopus, the later cases tended to be in juvenile Xenopus, particularly those in experimental families.

¹ Supported by the Fonds national suisse pour la recherche scientifique (No. 2551).

² Present address: Virus Laboratory, University of California, Berkeley, California.

Received 7/29/64.