This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Karon, M. Articles by Henry, P. Search for Related Content PubMed PubMed Citation Articles by Karon, M. Articles by Henry, P.

Studies of DNA, RNA, and Protein Synthesis in Cultured Human Cells Exposed to 8-Azaguanine

( Medicine Branch and Metabolism Service, Department of Health, Education, and Welfare, U.S.P.H.S. National Cancer Institute, National Institutes of Health, Bethesda, Maryland)

Studies of the kinetics of DNA, RNA, and protein synthesis in KB cell spinner cultures exposed to 8-azaguanine were performed at doses of the analog which produced little or no inhibition of cell multiplication. The results indicated that, of the three factors studied, protein synthesis is most sensitive to inhibition by azaguanine. As in the case of Bacillus cereus, the analog was preferentially incorporated into soluble RNA (sRNA).

Received 8/19/64.