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Fate of Circulating Tumor Cells

III. Comparison of Metastatic Growth Produced by Tumor Cell Emboli in Veins and Lymphatics¹

( Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 4, Pennsylvania)

Experiments were designed to determine the relative ability of tumor cell emboli in blood and lymph to produce metastases. The transplantable V₂ carcinoma was used in domestic rabbits. Equal volumes of the same suspension were injected into veins of some rabbits and into lymphatics of others. The rabbits were sacrificed later and the incidence of metastasis was determined. Under these circumstances, metastases occurred with significantly greater frequency in rabbits receiving the injection I.V. than in those which received the tumor into lymphatics. The experimental results suggest that some tumor cell emboli are destroyed in the lymph node.

¹ This investigation was supported by grant C-2356 from the Division of Research Grants and Fellowships of the National Institutes of Health, USPHS.

Received 10/ 9/64.