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The Usefulness of Tissue Culture Cell Lines in the Development of Ascites Tumors from a Transplantable Squamous Cell Mouse Carcinoma¹

( Department of Pathology—Cytology Section, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania)

Ascites tumors were successfully produced by using tissue culture Cell Line 70, obtained from a transplantable squamous cell carcinoma of the mouse. The derived tissue culture cell lines with described tumorigenic properties were also developed from ascitic and solid tumors resulting from the inoculation of mice with Cell Line 70. The use of cell lines for the production of ascites tumors from squamous cell carcinoma is valuable for the comparative study of tumor differentiation under in vivo and in vitro conditions.

¹ This study was supported by a research grant, CY-3654, from the National Cancer Institute, NIH, Bethesda, Md.

Received 10/19/64.