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Chemotherapeutic Effects on Mammalian Tumor Cells

II. Biologic and Chromosomal Instability of a Cyclophosphamide Treated Murine Leukemia

(From the Radiation Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland)

Murine leukemia L1210 has been treated with cyclophosphamide and 4 sublines have been developed from the tumor cells surviving drug therapy. Biologic studies have demonstrated a marked alteration of virulence compared to the parent tumor and striking cytogenetic modifications have been found to exist. Serial examinations over an interval of 22 weekly transplant generations have demonstrated a biologic and cytogenetic instability characterized by, generally, a tendency for return toward control values.

Received 11/19/64.