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Mitotic Rate and Doubling Time of Intraperitoneal and Subcutaneous Ehrlich Ascites Tumor¹

( Department of Anatomy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada)

The doubling time of the cell population of an Ehrlich tumor, grown both in ascitic form and as a solid tumor, was ascertained by the colchicine technic. The doubling time of the ascitic tumor cell population was determined to be 21 hr, and was within similar range of that observed in several previous investigations. Transplanting the tumor cells into the subcutaneous fascia, where they formed a solid tumor, prolonged the doubling time to 29 hr. The duration of the mitotic phase of Ehrlich ascites tumor cells was of the magnitude of 75 min. In neither tumor form were diurnal variations of mitotic activity observed.

Previous investigations of the cell cycle of Ehrlich tumor cell populations are reviewed, and by combining various observations, an attempt is made to state an approximate mean duration for each phase of the cell cycle.

¹ This investigation was supported by a research grant from the National Cancer Institute of Canada, Toronto.

Received 12/ 8/64.