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Action of 1-ß-D-Arabinofuranosylcytosine on the Nucleic Acid Metabolism and Viability of HeLa Cells

( Biophysics Division, Sloan-Kettering Institute for Cancer Research, New York, New York)

Exposure of HeLa S-3 cells to 1-ß-D-arabinofuranosylcytosine (ara-C) produced a loss of cell viability accompanied by an inhibition of deoxyribonucleic acid (DNA) synthesis. Continued synthesis of ribonucleic acid (RNA) and protein strongly suggests an "unbalanced growth" syndrome with a deficiency in the deoxycytidylate moiety analogous to thymidylate-deficient states previously reported with 5-fluorodeoxyuridine and amethopterin. Exposure to ara-C under appropriate conditions yields a partial synchronization of this mammalian cell culture.

Received 12/12/64.

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				D. Kessel, T. C. Hall, and I. Wodinsky Transport and Phosphorylation as Factors in the Antitumor Action of Cytosine Arabinoside Science, June 2, 1967; 156(3779): 1240 - 1241. [Abstract] [PDF]