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Effect of Azaserine on the Fine Structure of the Liver and Pancreatic Acinar Cells¹

(From the Department of Pathology and Whitman Laboratory, University of Chicago, Chicago, Illinois)

Intraperitoneal administration of azaserine to adult rats resulted in characteristic alterations of rough endoplasmic reticulum, large areas of focal degradation and formation of osmiophilic plaques in pancreatic acinar cells. The hepatocytes showed a marked enlargement of the crystalloid of microbodies, disorganization of endoplasmic reticulum and focal degradation. The lesions were similar to those produced by ethionine. Oral administration of azaserine produced a similar but less drastic change.

¹ Supported by USPHS Grants CA-05310 and CA-03544 from the National Cancer Institute.

² Work performed during tenure of Advanced Clinical Fellowship of the American Cancer Society.

Received 12/18/64.