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The Interstitial Water Space of Tumors

( Tumor-Host Relation Section, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland)

The interstitial water space of 3 hepatomas, Walker carcinoma 256, and fibrosarcoma 4956 in rats was estimated as the difference between the extracellular and the vascular water spaces. The vascular water space was measured with high molecular weight. The extravascular water space was evaluated by the use of ²⁴Na, ³⁶Cl, and D-mannitol-1-¹⁴C as markers. The ²⁴Na space was the smallest in all cases although in some of the tumors the distribution space of all 3 markers was the same. The interstitial water space of all specimens studied was very large, between 32 and 60% of the tumor water, depending on the tumor type. In hepatomas, the interstitial water space represented 40–55% of the tumor water and was 3–4 times larger than that of the liver. The ratio between vascular and interstitial water spaces was about 1.0 in the liver but only 0.1 in hepatomas. The reduction resulted from a decrease of the vascular and an increase of the interstitial water space.

Received 7/ 7/64. Revised 12/22/64.

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