This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Burke, W. T. Articles by Gangloff, E. C. Search for Related Content PubMed PubMed Citation Articles by Burke, W. T. Articles by Gangloff, E. C.

Metabolic Profiles during Carcinogenesis and Related Conditions in Hepatic Tissue¹

( Laboratory of Experimental Pathology and Department of Biochemistry, New York Medical College, New York, New York and Department of Biochemistry, West Virginia University Medical Center, Morgantown, West Virginia)

An extensive series of rat liver perfusions has been carried out using livers from normal rats, livers from rats treated with carcinogens or carbon tetrachloride, or from rats following partial hepatectomy or bile duct ligation. The metabolic fate, in terms of urea and carbon dioxide production and liver and plasma protein synthesis, of 15 amino acids was determined for each liver condition. Although the results in general are similar, in that enhanced incorporation of amino acids into liver and plasma proteins and decreased amino acid catabolism are features common to most of the liver types, when the metabolism of specific amino acids was investigated it was found that each liver type was associated with a characteristic biochemical defect or metabolic deviation from normal. The data provide evidence that different hepatic carcinogens may have similar over-all effects but the basic metabolic lesions in each case are related to the carcinogen used. The data also provide an indication of the cell of origin of the tumor on the basis of the associated metabolic changes.

¹ Supported by grant No. CA 05606-05 PC from the National Cancer Institute of the USPHS.

Received 12/23/64.