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Papilloma-like Virus from Bovine Urinary Bladder Tumors¹

( Department of Veterinary Science, University of Wisconsin, Madison, Wisconsin)

Suspensions of 6 spontaneous bovine urinary bladder tumors produced fibropapillomas of the skin and vagina as well as polypoid growths with fibroma in the urinary bladders of test calves. The induction period ranged from 25 to 111 days. Three serial animal passages of one isolate which was filterable did not increase the activity of the virus. The infective agent resembles the bovine wart virus in its behavior in test calves and may be a causative factor in the etiology of spontaneous bladder tumors or it might simply be a passenger virus. Material from 10 other spontaneous bovine urinary bladder tumors were inactive.

¹ Published with approval of the director of the Wisconsin Agricultural Experiment Station. Supported with the aid of RG. CA 4627, NIH, the Research Committee of the Graduate School with funds from Wisconsin Alumni Research Foundation (administered by the University of Wisconsin) and grant FG-TU-102 of the U.S. Department of Agriculture, Agricultural Research Service, (administered by the University of Ankara).

² On leave from Veterinary Faculty, University of Ankara, Ankara, Turkey.

³ Present address: School of Veterinary Science and Medicine, Purdue University, Lafayette, Ind.

Received 12/23/64.