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Directional Movement of Cells as Affected by Aggregation and Dispersal¹

( Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104)

The effect of clumping and scattering upon the paths taken by polymorphonuclear leukocytes was studied in slide-coverslip preparations. Scattered cells moved at random. Clumped cells moved away from the location of the cluster. The evidence seemed to justify the conclusion that the cells were displaying negative chemotaxis to some substance diffusing from the cluster, presumably a metabolite. The possibility that the outward migration of neoplastic cells from the central tumor may depend upon a similar mechanism is presented.

¹ This research was supported by Grant CA-03562 from the NIH, USPHS.

Received 1/15/65.