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The Enhanced Response of the Ridgway Osteogenic Sarcoma to Roentgen Radiation Combined with Actinomycin D¹

(The Children's Hospital Medical Center, The Children's Cancer Research Foundation, and the Departments of Radiology and Pathology, Harvard Medical School, Boston, Massachusetts)

A series of experiments is reported in which X-radiation, actinomycin D, and their combination were used in the treatment of mice bearing the Ridgway osteogenic sarcoma. This tumor responds well to treatment with either of the 2 modalities; "therapeutic synergism," as judged by tumor inhibition and increase in survival time, is obtained with combination therapy. The augmentation of therapeutic response was found to be independent of the sex of the tumor-bearing animal, the order in which the 2 treatments were given, the time interval up to 24 hr which separated the 2 treatments and the parenteral route used for the administration of actinomycin D. Retreatment with the combination during a period of tumor regression occasioned by a first course led to a high percentage of "cures" in animals thus treated.

¹ This investigation was supported in part by research grants from the National Cancer Institute, NIH, USPHS, Nos. CY-3335 and C-6516.

² Present address: University of Minnesota Hospitals, Minneapolis, Minn.

Received 6/10/64. Revised 3/30/65.