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Oncogenic Effects of 4-(p-Dimethylaminostyryl)quinoline (4M20) in Mice¹

( Biology Division, Oak Ridge National Laboratory, and National Cancer Institute-Atomic Energy Commission Co-Carcinogenesis Project, Oak Ridge, Tennessee)

RF and 101C3F₁ mice which survived midlethal amounts of 4-(p-dimethylaminostyryl)quinoline (4M20), received when they were 3 months of age, showed the following long term changes: (a) acute hepatotoxic effects followed by marked liver abnormalities, which included a high incidence of hepatoma, liver nodularity, fatty liver, irregularities of parenchymal cell and nuclear size, and an increased incidence of nuclear inclusion bodies; (b) shortening of the mean life span (16%) in RF mice but not in 101C3F₁ mice; (c) small increase in incidence of reticular, ovarian, and lung neoplasms, giving a rather marked over-all increase in total neoplasm incidence in 101C3F₁ mice; (d) an increase in the frequency of thymic lymphomas and ovarian tumors and a decrease in the frequency of reticulum cell tumors in RF mice.

¹ Research jointly sponsored by the National Cancer Institute under an Atomic Energy Commission-National Institutes of Health contract and by the U. S. Atomic Energy Commission under contract with the Union Carbide Corporation.

² Present address: Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.

Received 12/21/64.