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Effect of Fluoropyrimidines on Delayed Cutaneous Hypersensitivity¹

( Division of Clinical Oncology and Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin)

The ability to express delayed cutaneous hypersensitivity was assessed in 51 patients with carcinoma. Evidence is presented that 5-fluorouracil and 5-fluoro-2'-deoxyuridine paradoxically potentiate this parameter of immune responsiveness.

¹ This study was supported in part by Grants CA 06749-02 and 1-K3-CA-21,950 from the National Cancer Institute, USPHS, Bethesda, Md.

² Surgeon, National Cancer Institute, USPHS. Present address: Department of Medicine, University of Rochester Medical Center, Rochester 20, N.Y.

³ Career Research Development Awardee, USPHS.

Received 1/25/65.