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The Role of the Phagocyte in Host-Parasite Interactions¹

III. The Phagocytic Capabilities of Leukocytes from Myeloproliferative and Other Neoplastic Disorders

Department of Pathology and Medical Research, St. Margaret's Hospital, and Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts

The phagocytic capabilities of leukocytes from a number of myeloid and monocytic leukemias and from neoplastic and other disease states have been studied. For comparative purposes phagocytic and bactericidal rates were determined on a series of normal leukocyte populations. By use of the method of least squares, a line of regression was calculated over a selected bacteria-to-phagocyte ratio. The standard error of the estimates was calculated, and 2 standard errors of the mean were arbitrarily established as a trend boundary. Thus, any subsequent result that did not fall within this boundary was considered abnormal, and conversely any result that did fall within this boundary was considered normal.

Contradictory to our previous results with the lymphoproliferative disorders, where altered phagocytic patterns were generally frequent, normal clearance and killing rates were generally obtained in this study, although some abnormality in over-all phagocytic activity did occur. However, when decreased phagocytic and bactericidal rates were observed, the alteration was more frequent when Pseudomonas aeruginosa was the test organism. Also, some abnormality in clearance kinetics under the conditions studied was noted when leukocytes were obtained from patients with acute leukemia.

¹ This investigation was supported by USPHS research grant CA-05307 from the National Cancer Institute.

² Charlton Fellow, Department of Obstetrics and Gynecology, Tufts University School of Medicine.

³ Formerly of Blood Research Laboratory, New England Center Hospital, Boston, Mass.; present address: Mount Zion Hospital, San Francisco, Calif.

Received 1/14/65.