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Natural and Synthetic Chemical Carcinogens in the Etiology of Cancer¹

McArdle Memorial Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin

This review is concerned with natural and synthetic chemicals in the etiology of cancer, with particular attention focussed on products and situations which may relate to man. The carcinogenic activities of certain aromatic polycyclic hydrocarbons and aromatic amines for both man and experimental animals have been known for several decades. More recently the discoveries of a number of carcinogenic metabolites in various forms of life have stimulated interest in this aspect of environmental carcinogenesis. These natural products include certain metabolites of tryptophan, various mold metabolites (aflatoxins, griseofulvin, and several uncharacterized compounds), and a variety of plant products (certain pyrollizidine alkaloids, cycasin, safrole, and thiourea). Theories on the possible means by which chemicals may induce cancer are discussed.

¹ The work of the authors in the field of chemical carcinogenesis has been supported by Grant CA-07175 of the National Cancer Institute, USPHS; by a grant from the Jane Coffins Childs Memorial Fund for Medical Research; and by the Alexander and Margaret Stewart Trust Fund.

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