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Formal Discussion of: Somatic Mutations and Carcinogenesis¹

Biology Department, Brookhaven National Laboratory, Upton, New York

A great deal of evidence is now available indicating that mutations play a dominant role in the aging process. Because carcinogenesis is one facet of the aging process, mutations must play a major role here also. However, carcinogenesis certainly does not consist of the simple induction of a mutation in one cell which confers the property of uncontrolled growth on that cell and its progeny. There must be some general conditions, as well as a specific event, before carcinogenesis can take place. It is postulated that mutations in one form or another are responsible for both conditions.

¹ The research reported in this paper was carried out at Brookhaven National Laboratory under the auspices of the U.S. Atomic Energy Commission.

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