This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Papac, R. J. Articles by Welch, A. D. Search for Related Content PubMed PubMed Citation Articles by Papac, R. J. Articles by Welch, A. D.

Effects of 1-ß-D-Arabinofuranosylcytosine Hydrochloride on Regenerating Bone Marrow¹

Department of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut

1-ß-D-Arabinofuranosylcytosine (ara-C³ or cytosine arabinoside), a pyrimidine nucleoside analog, is capable of inhibiting marrow regeneration in lethally irradiated mice in which marrow recolonization by donor marrow cells from normal mice occurs. When administered on the 4th day after irradiation and marrow injection, the drug induces significant marrow suppression. Depending upon the relative amounts of the compounds and the intervals of time between their administration, reversal of the effect of cytosine arabinoside on the bone marrow can be accomplished by deoxycytidine. When the metabolic block induced by cytosine arabinoside is circumvented by deoxycytidine, with release of the biosynthesis of DNA, the administration of certain cytotoxic agents yields enhanced suppression of the regenerating bone marrow of mice.

¹ Supported by USPHS Grants CA-02817, CA-05944, CA-5138, and MO-FR38.

³ The abbreviations used are: ara-C, cytosine arabinoside (1-ß-D-arabinofuranosylcytosine hydrochloride); DNA, deoxyribonucleic acid; CdR, 2'-deoxycytidine; IUdR, 5-iodo-2'-deoxyuridine; HN2, nitrogen mustard.

² Burroughs Wellcome Scholar in Clinical Pharmacology.

Received 12/23/64. Revised 5/13/65.