This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kensler, C. J. Articles by Wodinsky, I. Search for Related Content PubMed PubMed Citation Articles by Kensler, C. J. Articles by Wodinsky, I.

Toxicology of Anti-leukemic Agents with Special Reference to Phthalanilide Derivatives¹

Life Sciences Division, Arthur D. Little, Inc., Cambridge, Massachusetts

Some of the toxicologic problems associated with the use of newer agents such as the phthalanilides have been presented. In lieu of the discovery of anti-leukemic agents with much improved therapeutic indices, it is perhaps encouraging in terms of potential combination therapy that limiting toxicologic problems differ. Methods have been developed or adapted which indicate that these toxicologic problems may not be associated with all structurally related compounds with anti-leukemic activity. It is suggested that the area of selective reduction in toxicity by the administration of toxicity-alleviating agents merits increased attention.

¹ The experimental studies included in this report have been supported by contract SA-43-ph-3789, Cancer Chemotherapy National Service Center, National Cancer Institute.