This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Freeman, G. Articles by Sultanian, I. Search for Related Content PubMed PubMed Citation Articles by Freeman, G. Articles by Sultanian, I.

Response of Tumorigenic Viruses and of Cells to Biologically Active Compounds. I. Methods for Determining Response and Application of Methods¹

Methods were applied for assessing the responses of cell-virus systems in culture to subtoxic, i.e., threshold, concentrations of 65 biologically active compounds. The systems were a pair of tumorigenic viruses, Rous sarcoma (RSV) and polyoma (PYV), and a pair of lytic viruses, encephalomyocarditis (EMCV) and vaccinia (VV). RSV and EMCV are ribonucleic acid viruses; PYV and VV are deoxyribonucleic acid viruses. RSV and VV were assayed in chick cells and PYV and EMCV in mouse cells. The viral species had a major influence on response, the type of viral nucleic acid was of secondary importance, and the host species had a negligible influence.

¹ Supported by contract PH-43-65-43 from the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.

² Department of Medical Sciences, Stanford Research Institute, Menlo Park, California.