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The Antigenic Stability of 3 AKR Leukemias on Isotransplantation and the Serologic Detection of Thymus-derived Leukemia Cells¹

Biochemistry Section, Department of Surgery, Tufts University School of Medicine, and the First (Tufts) Surgical Service, Boston City Hospital, Boston, Massachusetts

The concentrations of certain cell surface isoantigens of 3 AKR leukemias have been studied in transplant generations 1–5 and 28–35. Two quantitative methods were used for this purpose: immune cytolysis of leukemia cells by isoantisera, and absorption of isoantisera by these cells.

Although certain biologic properties of the 3 leukemias showed definite progression, only a relatively slight decrease in antigenic content was found. However, the isoantigens studied may have been irrelevant to tumor progression, and simplification of other antigens may have occurred.

A serologic method that permits recognition of thymus-derived leukemic lymphocytes in admixture with isogenic normal lymphocytes has been tested.

¹ This investigation was supported by USPHS Research Grant CA 04469-06 AI from the National Cancer Institute.

Received 3/15/65. Revised 7/16/65.