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The Fragility of Normal and Leukemic Lymphocytes of AKR Mice: A Study of Cell Injury by Physical Agents¹

Biochemistry Section, Department of Surgery, Tufts University School of Medicine, and the First (Tufts) Surgical Service, Boston City Hospital, Boston, Massachusetts

The resistance of single cell suspensions to osmotic and thermal injury has been determined by use of vital dye exclusion to document the integrity of the cell surface.

Four newly derived leukemias possessed a resistance to injury by these physical agents that was similar to that of normal marrow cells, but higher than that of various types of normal lymphocytes. On continued isotransplantation, all 4 leukemias progressed to a higher resistance to such injury.

¹ This investigation was supported by USPHS Research Grant CA 04469-06AI from the National Cancer Institute.

Received 3/15/65. Revised 7/16/65.