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Some Immunologic Aspects of Canine Neoplasms¹

Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, and Division of Laboratories, Pennsylvania Department of Health, and Department of Microbiology, Temple University School of Medicine, Philadelphia, Pennsylvania

At least 1 unique soluble antigen has been demonstrated in approximately 20% of canine neoplasms. Similar material was not demonstrated in a variety of nonmalignant adult canine tissues. The antigen is apparently similar to, but not identical with, the G antigen found in some human neoplasms. The presence of the unique canine tumor antigen bore no relation to the pathologic diagnosis of the tumor, a finding that is analogous to that derived from studies on the G antigen.

Circulating antibodies to venereal sarcoma were found by conglutinating complement adsorption tests in the sera of dogs carrying the tumor.

Some of the implications of these findings are discussed in the light of a possible viral alteration of the tumor cells inducing tumor-specific antigens.

¹ Supported in part by Grant T-264 of the American Cancer Society and by USPHS Grant C-5922 and C-08161.

Received 3/12/65. Revised 7/21/65.