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A New Transplantable Mouse Liver Tumor of Spontaneous Origin¹

Division of Experimental Chemotherapy and Division of Special Studies, Sloan-Kettering Institute for Cancer Research, and Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University Medical College, New York, New York

A transplantable primary liver tumor 1st observed in a 2-month-old female Swiss-Webster mouse is described. Morphologically, it was poorly differentiated. It was easily converted into an ascitic form. The tumor grew rapidly and uniformly without regression in 100% of Swiss-Webster mice after the 2nd transplant generation. Several characteristics of this tumor distinguish it from other transplantable primary liver tumors of the mouse; growth was rapid and invasive, and by Generation 4 no host-conditioning (X-irradiation and/or cortisone) was required; strain specificity was minimal, with progressive tumor growth in 100% of C3HeB/FeJ, DBA/2J, C57BL/6 Millerton, AKR/J, and C56BR/cdJ inbred, and in ICR/Ha Swiss random-bred mice.

¹ This study was supported in part by Research Grant CY-3784 from the National Cancer Institute, USPHS, Bethesda, Maryland.

² International Postdoctoral Research Fellow, U. S. Department of Health, Education and Welfare, Public Health Service, Bethesda, Maryland. Present address: Department of Pathological Anatomy, Catholic University, Voer des Capucins 37, Louvain, Belgium.

Received 3/23/65. Revised 7/29/65.

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